Recombinant Factor VIIa for The Management of Uncontrollable Bleeding Following The Repair of Acute Type A Aortic Dissection

Background: Bleeding is a serious complication after surgical repair of acute type A aortic dissection. Recombinant factor VIIa (rFVIIa) could be used for the management severe bleeding; however, it lead to thromboembolic events. We aimed report our experience in using rFVIIa bleeding following dissection.
 Methods: performed retrospective study, including patients who had surgery dissection and received rFVIIa, period between January 2012 2019. reported amount 4 hours before administration number blood products transfused use thrombosis central venous line, as well presence disseminated intravascular coagulation.
 Results: There were ten (2 females 8 males) out 120 with dissection, required postoperative bleeding. The mean age was 67.7±10.5 years. drainage decreased from 889±585.6 ml during prior infusion, 165±73.5 (p<0.001). 2752±1362.9 ml, 618±483.3 packed RBCs administration, respectively (p< 0.001). 1601±693.4 246±419.6 fresh frozen plasma prothrombin time infusion (42.7±32 17.1±8 seconds, p= no clinical signs thromboembolism its use. Mortality occurred five (50%).
 Conclusion: In life-threatening situation uncontrollable may have benefits control Furthers studies are recommended.